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KMID : 0880220120500050878
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Journal of Microbiology
2012 Volume.50 No. 5 p.878 ~ p.881
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Regulatory characteristics of the Vibrio vulnificus rtxHCA operon encoding a MARTX toxin
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Park Jin-Seo
Kim Seung-Min
Jeong Hee-Gon
Choi Sang-Ho
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Abstract
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Vibrio vulnificus MARTX encoded by rtxA, an open reading frame of the rtxHCA operon, is essential for virulence in vitro and in mice. In this study, a primer extension analysis revealed that transcription of the rtxHCA operon begins at a single site, and is under the direction of a single promoter, PrtxHCA. PrtxHCA activity appeared at the beginning of growth and reached a maximum in mid-exponential phase. PrtxHCA activity was induced by exposure to INT-407 cells, and the membrane fraction of INT-407 cells was the most effective for the induction.
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KEYWORD
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V. vulnificus rtxA, MARTX
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